Siblings

First off the comic starts with the biggest question of the game. Who are these people? And why do the sorta look like Isaac when shaped normally? Theorized answer: They're your brothers(and maybe sisters too). Regardless Artemis and Matt are based off of "gapers". Ye old demonic child with missing eyes, nothing new here. Just don't be fooled by their funny demeanor. for in actuality...
Thankfully, only Artemis' last line didn't get read.
"Really, It's been like that for like, ever"